| 학회 |
한국화학공학회 |
| 학술대회 |
2002년 가을 (10/24 ~ 10/26, 서울대학교) |
| 권호 |
8권 2호, p.3909 |
| 발표분야 |
생물화공 |
| 제목 |
Analysis of doxorubicin biosynthetic gene cluster and intensive study of regulatory system of Streptomyces peucetious ATCC 27952 |
| 초록 |
Streptomyces peucetious is responsible for producing clinically important chemotherapeutic agents, daunorubicin and doxorubicin , adraimycin. We sequenced 8.2.Mb, 95% of this organism, including comparative study with the previously disclosed biosynthetic gene cluster of doxorubicin. The abundance of previously uncharacterized primary metabolic enzymes is a resource of enormous potential value for further investigation. Mutant of regulatory gene of SARP family is developed for other proteomics investigations. We recognized the GARP, y-butyrolactone auto regulatory proteins which also control the production of antibiotics. |
| 저자 |
Niranjan Parajuli1, Young-Ho Moon2, Jin Suk Woo, Byung Gee Kim, Hei Chan Lee, Kwangkyoung Liou, Jae Kyung Sohng
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| 소속 |
1Institute of Biomolecule Reconstruction, 2SunMoon Univ. |
| 키워드 |
biosynthetic pathway; regulatory gene; doxorubicin; y-butyrolactone
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| E-Mail |
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| 원문파일 |
초록 보기 |
