| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Development of hybride BPEI- SNT as an efficient gene delivery carrier and imaging agent |
| 초록 |
We developed a hybrid polymer-silica nanotube(SNT) for dual purpose: an efficient gene delivery carrier and imaging agent. The outer surface of the SNT was covalently conjugated with cationic polymer, branched polyethylenimine (BPEI, MW 1.8k), so that it would easily load pDNA and transport the cargo into the cells. Additionally, the inner space of the SNT was filled with iron oxide nanoparticles and green fluorescent quantum dots. These two caged materials could be used simultaneously for imaging the cell with internalized SNT by MRI, as well as by fluorescence. |
| 저자 |
남궁란1, Kaushik Singha1, 박인규2, 손상준3, 김원종1
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| 소속 |
1포항공과대, 2전남대, 3경원대 |
| 키워드 |
Gene delivery; Silica Nanotube; PEI
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| E-Mail |
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