| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
대학원생 구두발표 |
| 제목 |
NONOates-hydrogel for Controlled Release of Nitric Oxide and its Application. |
| 초록 |
Recently, many scientists developed a lot of systems to control the release of nitric oxide (NO) which inhibits the proliferation of vascular smooth muscle cells, the apoptosis of vascular endothelial cells, and aggregation of platelet. Here, a novel NO-conjugated gel system was developed by using branched polyethyleneimine (BPEI) and pluronic F127. BPEI was easily conjugated to F127 via p-nitrophenylchloroformate (p-NPC) chemistry and F127-BPEI-NONOates was synthesized by high pressure of NO to form the diazeniumdionates (NONOates) in secondary amine sites. NO-conjugated gel system could reduce initial burst of NO release in respect of concentration and show the selective functions in smooth muscle cells and endothelial cells. That is, this local system for delivering the NO has a great potential in several biomedical applications due to the low cytotoxicity and selective functions of NO without leaking out of cytotoxic small molecules. |
| 저자 |
김지훈1, 이양기2, Kaushik Singha1, 한동근2, 김원종1
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| 소속 |
1포항공과대, 2한국과학기술(연) |
| 키워드 |
Nitric Oxide; NONOate; hydrogel; restenosis
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| E-Mail |
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