| 초록 |
A biodegradable polyurethane, which is classified as a pseudo poly(amino acid), has been developed using L-tyrosine. LTU2a is designed to degrade through hydrolysis and enzymatic mechanisms since a peptide bond since the backbone of the polymer contains a peptide bond. Nanoparticles encapsulated the pDNA-linear polyethylenimine (plasmid DNA-LPEI) complex. In addition, the surfaces have been modified with PEG. After 14 days, 15 of DNA per mg of nanoparticles have been released from the LTU2a nanoparticles. Moreover, a successful uptake of LTU2a nanoparticles by the hepatic (LX2) cells has been confirmed with confocal laser microscope, hepatic (HepG2) cells and breast (MCF7) cells has been confiremed with confocal. These characteristics are ideal for devliery systems designed to transport and release drugs in the cytoplasm. Therefore, LTU2a nanoparticles could be a promising for gene-delivery applications that require sustained release of DNA for the duration of a cell’s lifetime. |
