| 학회 | 한국화학공학회 |
| 학술대회 | 2009년 가을 (10/22 ~ 10/23, 일산 KINTEX) |
| 권호 | 15권 2호, p.1387 |
| 발표분야 | 공정시스템 |
| 제목 | Metabolic Pathway Identification Based on Thermodynamic Properties |
| 초록 | An effective strategy comprising two phases is proposed to determine the thermodynamically dominant pathways in a metabolic network involving a number of metabolic reactions. In the first phase, stoichiometrically feasible metabolic pathways are exhaustively identified through the flux balance analysis and the graph-theoretic method based on P-graphs. In the second phase, thermodynamically dominant pathways are selected from these stoichiometrically feasible metabolic pathways on the basis of the Gibbs free energy change of reaction. The proposed strategy’s efficacy is demonstrated by applying it to two E. coli models. ACKNOWLEDGEMENT : This work was supported by the Korean Systems Biology Research Program (M10309020000-03B5002-00000) of the Ministry of Education, Science and Technology (MEST). Further supports by LG Chem Chair Professorship, Microsoft, World Class University Program of MEST and IBM-SUR program are greatly appreciated. |
| 저자 | 윤좌문1, L.T. Fan2, Tengyan Zhang3, 김 영4, 김태용1, 이상엽1, 박선원1, Ferenc Friedler5, Botond Bertok5 |
| 소속 | 1한국과학기술원, 2Kansas State Univ., 3Western Research Institute, 4한국기계(연), 5Univ. of Pannonia |
| 키워드 | Metabolic flux analysis; Gibbs free energy; Process graphs; E. coli. |
| 원문파일 | 초록 보기 |
