| 학회 | 한국공업화학회 |
| 학술대회 | 2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 22권 2호 |
| 발표분야 | (국제협력위원회) 우수외국인연구자세션 |
| 제목 | Co-immobilization of heparin and silver nanoparticles onto poly(urethane) surfaces for reduced thrombosis and bacterial infections |
| 초록 | The quest to prevent the thrombosis and bacterial infections is important due to the fast growth in the cases of thrombosis and infection associated with medical implants. In this study, we reported an efficient therapy to impart antithrombotic and antimicrobial properties to substrates, by simultaneously immobilizing heparin and silver nanoparticles (AgNPs) via a tyrosinase (Tyr)-catalyzed reaction. Tyr oxidized phenol groups of heparin grafted tyramine (HT) to catechol groups, followed by immobilizing HT and inducing the in situ AgNP formation onto poly(urethane) (PU) substrates. The successful immobilization was confirmed by analyses of water contact angles, XPS and SEM. The immobilized surfaces showed significant reduction in platelet adhesion and remarkable antibacterial properties. The results from this work suggest a novel method to fabricate a new generation of medical devices with antithrombotic and antibacterial activities. Acknowledgement: MSIP(NRF-2015M3A9E2028578) |
| 저자 | Le Thi Phuong1, 이윤기1, 박경민2, 박기동1 |
| 소속 | 1아주대, 2인천대 |
| 키워드 | heparin; silver nanoparticles; surface modification |
