| 학회 | 한국공업화학회 |
| 학술대회 | 2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 | 25권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Calcium Peroxide-Mediated In Situ Forming Hydrogels with Accelerated Mesenchymal Stem Cell Behaviors and Antibacterial Properties |
| 초록 | Horseradish peroxidase (HRP) and hydrogen peroxide (H2O2)-catalyzed hydrogelation serves jnjectable hydrogels as therapeutic vehicles/implants. Herein, we utilize calcium peroxide (CaO2) as H2O2 generation source for HRP-mediated reaction to create stiff hydrogels without cytocompatibility. The physico-chemical properties of hydrogels are controlled by varying HRP and CaO2 concentrations. The controlled and sustained release of H2O2, O2, and Ca2+ from hydrogels could stimulate the cellular behaviors (attachment, migration, differentiation) of mesenchymal stem cells. Moreover, the hydrogels exhibited killing efficacy against both gram-negative and gram-positive bacteria. These results suggest that HRP/CaO2 – catalyzed hydrogels are potential for various biomedical applications, such as bone regeneration and infectious treatment. Acknowledgement: 2019R1A6A1A11051471, 202012A01 |
| 저자 | Le Thi Phuong1, Tran Dieu Linh1, 박경민2, 박기동1 |
| 소속 | 1아주대, 2인천대 |
| 키워드 | injectable hydrogels; HRP; CaO2; cellular behaviors; antibacterial |
