| 학회 |
한국화학공학회 |
| 학술대회 |
2020년 가을 (10/14 ~ 10/16, e-컨퍼런스) |
| 권호 |
26권 1호, p.309 |
| 발표분야 |
생물화공 |
| 제목 |
Formation of multiple emulsion droplets in micromolds via surface tension and polymer fluid phase separation |
| 초록 |
This paper presents a simple and rapid method to manipulate multiple emulsion droplets in micromolds utilizing the phase separation of fluids and droplet formation by surface tension. We used a cross-shaped micro-mold containing a prepolymer solution in which the phase is separated into two compartments when the wetting liquid containing a separating agent (SA) is added. As a result, Laplace pressure driven flow creates double emulsion droplets. The size of each compartment of emulsion is controlled to produce double emulsion with varying shell thickness by adjusting the composition of the prepolymer solution and SA. The phase separation creates two compartments with different polarities, allowing hydrophilic/hydrophobic cargo to be encapsulated in the desired compartment. In addition, we produce poly(N-isopropylacrylamide) (pNIPAm) hydrogel microcapsules by solidifying the middle phase in the double emulsion. Thus, hydrophilic cargo preloaded in the core can be encapsulated within a hydrogel shell. Finally, we successfully achieve encapsulation of small cargo via post-loading approach by taking advantage of hydrophilic-hydrophobic phase transition behavior of pNIPAm. |
| 저자 |
정성근1, 이창수1, 최윤2, 남진오1, 최창형2
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| 소속 |
1충남대, 2대구한의대 |
| 키워드 |
나노바이오 |
| E-Mail |
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| 원문파일 |
초록 보기 |
