| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터) |
| 권호 |
43권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Preparation and Anticancer effect of Pegylated-Chlorambucil Prodrug nanoparticle |
| 초록 |
Leukemia has been treated by Chlorambucil (CLB). According to recent studies, CLB reported that has anticancer effect against various cancer cells. However, CLB is limited because of the MDR effect, high toxicity, and low solubility in water. So, we designed pegylated-CLB (PCLB, mPCLB) prodrug by using coupling agents. Their chemical structure was analyzed by 1H-NMR and UV-vis spectrophotometer. In addition, dispersity of them against water with various concentration was confirmed by UV-vis spectrophotometer. Its particle size and morphological property were confirmed by using DLS and TEM. Cytotoxicity and anticancer effect were investigated by using MTT assay. Besides, to confirm their cellular uptake at cancer cell lines, FITC was labeled to prodrug and observed by fluorescence microscopy. These results suggest that they can apply as anticancer agent. (NRF-2016H1D5A1910499). |
| 저자 |
정경원, 정은희, 김준수, 홍웅길, 안준혁, 나재운
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| 소속 |
순천대 |
| 키워드 |
Chlorambucil; Pegylated-chlorambucil; Prodrug; Anticancer effect
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| E-Mail |
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