| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I (영어발표) |
| 제목 |
Heme Oxygenase 1-targeted Drug Delivery Systems for Acute Myeloid Leukemia Therapy |
| 초록 |
Acute myeloid leukemia (AML) is hematological malignancies with high mortality, and chemotherapy and bone marrow transplantation are available, and recently challenged with immunotherapy. Heme oxygenase 1 (HO1)-mediated cytoprotection has been demonstrated as a chemo-resistant mechanism in AML, and recently reported as an immune checkpoint molecule in tumor myeloid cell. In here, HO1-targeted drug delivery systems are developed for AML therapy. Firstly, human CD64-targeted single chain antibody fusion protein sR9 was complexed with HO1-targeting siRNA (siHO1). In human AML-bearing orthotopic model, sR9-mediated siHO1 delivery enhances chemotherapeutic effect of daunorubicin. Secondly, HO1-inhibitor-loaded nanoparticle (T-hNP) was prepared and modified for active targeting of AML. In human AML xenograft model, combination of T-hNP with daunorubicin shows dual chemo- and immuno-therapeutic effect. |
| 저자 |
Seok-Beom Yong1, Jaehyun Kim2, Yong-Hee Kim1
|
| 소속 |
1Department of Bioengineering, 2Hanyang Univ. |
| 키워드 |
- |
| E-Mail |
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