| 초록 |
18-Glycyrrhetinic acid(18β-GA) is a bioactive compound in licorice that exhibits poteintial anti-cancer, anti-inflammatory, and anti-microbial activities. Recently, 18β-GA is proved to enhance the proliferation of dermal fibroblasts and derivative promoted the migration of fibroblasts. However, 18β-GA have been reported be cytoxic and hydrophobic property. We employed 18β-GA as a contained compound in liposomes, then coated the ethosome with modified functionality polymer. Because, the liposome can improve the bioactivity of hydrophobic compounds and modulate amount of release drug, and residue on treated wound part by using glucose of wounded skin for long time. we explored wound healing efficiency, stability and formulatinon character of these ethomses. |
