| 학회 |
한국화학공학회 |
| 학술대회 |
2018년 가을 (10/24 ~ 10/26, 대구 EXCO) |
| 권호 |
24권 2호, p.1512 |
| 발표분야 |
생물화공(Biochemical Engineering) |
| 제목 |
Bioengineered yeast derived lysosome as nanocarrier for cancer therapy |
| 초록 |
Recent decades, there are advancements in field of synthetic nanomaterials for cancer therapy. Despite the progress of synthetic nanomaterials for cancer therapy, there are immunological problems and engineering limitations. So we study biologically derived nanocarriers come from recombinant yeast that overcome such hurdles. Saccharomyces cerevisiae contains vacuoles corresponding to lysosomes that have similar to the lipid composition of mammalian cell membranes, efficiently release of drug into tumor tissues. We genetically modified yeast gene for nanosized and load daunorubicin which used in treating acute myeloid leukemia. These intended lysosomes release the drug into cultured cancer cells. According to this study we make sure that bioengineered lysosomes can be more safe and potent drug carrier. This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Science, ICT & Future Planning(2017R1A2B4009775). |
| 저자 |
최우일1, 허미영2, 김양훈3, 민지호4
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| 소속 |
1전북대, 21Graduate School of Semiconductor and Chemical Engineering, 3Chonbuk National Univ., 4Jeonju 54896 |
| 키워드 |
생물화공 |
| E-Mail |
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| 원문파일 |
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