| 초록 |
ABSTARCT: A series of temperature responsive lipopolymer hybrid materials, 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-poly(N-isopropylacrylamide)n [DPPE-p(NIPAM)n], phosphatidylethanolamine-poly(N-isopropylacrylamide)n [PE-p(NIPAM)n] 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphoethanolamine-poly(N-isopropylacrylamide)n [Alkyne PE-p(NIPAM)n] (n=60,40,25) have been synthesized by the combination of radical polymerization and click chemistry. The lipids were modified to azide terminated lipids and alkyne terminated p(NIPAM) were synthesized by employing reversible addition-fragmentation chain transfer polymerization (RAFT) for the azide-alkyne click reaction. For the active targeting of cancer cells folic acid is tethered into the DPPE-p(NIPAM)n by employing thiol-ene click reaction. After the structural charecterisation by spectroscopy. The temperature induced self-assembly resulted in micelles (200 nm) capable of controlled release of hydrophobic drug doxorubicin. |
