| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Photosensitizer Loaded Cationic Dual Stimuli Responsive Lipopolymer Formulation for the Controlled Delivery of Ce6 in Tumor Targeted Photodynamic Therapy |
| 초록 |
In our study site specific cationic dual responsive photosensitizer loaded liposomal nanocarriers prepared for the controlled intracellular release of chlorine e6 (Ce6) in a targeted tumors related to their microenvironments. The system was developed by the formulation of phosphatidylcholine (PC), posphatidylethanolamine-p(L-Histidine)40 (PE-p(His)40), folic acid conjugated PE-p(N-isopropyl acrylamide)40 (PE-p(NIPAM)40). The designing features providing the promising properties such as cationic charges, membrane fusogensity and targetability of liposomal nanocarriers for the controlled delivery of Ce6 in tumors. The self-assembled nanostructure shows the diameter ranging from 90 to 140 nm. Interestingly, Ce6 release was enhanced at pH 6.6 owing to the protonation/deprotonation of imidazole in PE-p(His)40. In addition to that it shows significant photodynamic therapeutic efficiency on KB cancer cells than free Ce6. |
| 저자 |
Johnson V.J.1, 김일2
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| 소속 |
1BK21 플러스 동남권 화학신기술 창의인재양성사업단, 2부산대 |
| 키워드 |
lipopolymer; nanocarrier; stimuli responsive; photodynamic therapy
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| E-Mail |
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