| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
고분자합성 |
| 제목 |
Dual Stimuli-Responsive Vesicular Nanospheres Fabricated by Lipopolymer Hybrids for the Tumor-Targeted Photodynamic Therapy |
| 초록 |
Smart delivery system of photosensitizer chlorin e6 (Ce6) has been developed for targeted photodynamic therapy (PDT). Simple self-assemblies of the mixtures comprised of soybean lecithin derived phosphatidylcholine (PC), phosphatidylethanolamine–poly(L-Histidine)40 (PE–p(His)40) and folic acid (FA) conjugated phosphatidylethanolamine-poly(N-isopropyl acrylamide)40 (PE–p(NIPAM)40–FA) in different ratios yield smart nanospheres characterized by i) stable and uniform particle size (~ 100 nm), ii) high hydrophobic drug (Ce6) loading efficiency up to 45%, iii) covalently linked targeting moiety, iv) low cytotoxicity, and v) smartness showing p(His) block oriented pH and p(NIPAM) oriented temperature responsiveness. . The Ce6@VNS system showed significant photodynamic therapeutic efficiency on KB cells than free Ce6. A receptor-mediated inhibition study proved the site-specific delivery of Ce6 in targeted tumor cells. |
| 저자 |
김일1, Johnson V.J.2
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| 소속 |
1BK21 플러스동남권화학신기술 창의인재양성사업단, 2부산대 |
| 키워드 |
Cancer therapy; Lipopolymer; Photodynamic therapy; Stimuli responsive; Vesicle
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| E-Mail |
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