| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Fabrication of Monodisperse Magnetic Nanoparticles Ligand Exchanged with Synthesized Phosphatidylethanolamine(PE)-b-Polyglycidol-Folic acid(FA) for Enhanced MRI Contrast Agent |
| 초록 |
In this study, we designed magnetic nanoparticles (MNPs) not only for high magnetic resonance (MRI) contrast enhancement but also for excellent colloidal-stability in water and targeting capabilities. Preparing the monodisperse MnFe2O4 NPs with uniform size (7-10 nm) and defined morphology is via thermal decomposition of organometallic compounds such as Fe(acac)3, Mn(acac)2. Furthermore, We fabricated amphiphilic lipopolymer consisted with phosphatidylethanolamine-b-hyperbranched polyglycidol (PE-b-HBPG) by using anionic ring-opening multibranching polymerization (ROMBP) principle. After that, we conjugated folic acid (FA) on to the PE-b-HBPG for targeting tumor cells which have the ability to over-expressed the folate receptor. Finally, MnFe2O4 NPs were labeled with this PE-b-HBPG-FA by ligand exchange reaction to make NPs soluble in water and increase targetability through receptor-mediated cellular binding and uptake. |
| 저자 |
김일1, 이혜리2
|
| 소속 |
1BK21 플러스 동남권 화학신기술 창의인재양성사업단, 2부산대 |
| 키워드 |
Lecithin phosphatidylethanolamine; Hyperbranched polyglycidol; Magnetic nanoparticles; MnFe2O4; T2-weighted MRI contrast agent
|
| E-Mail |
|
