| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
고분자합성 |
| 제목 |
Folic acid Tethered Temperature Responsive Lipopolymer Hybrid Materials for Doxorubicin Delivery |
| 초록 |
A series of temperature responsive lipopolymer hybrid materials, DPPE-p(NIPAM)n, PE-p(NIPAM)n, Alkyne PE-p(NIPAM)n (n=60,40,25) have been synthesized by the combination of radical polymerization and click chemistry. The lipids were modified to azide terminated lipids and alkyne terminated p(NIPAM) were synthesized by employing reversible addition-fragmentation chain transfer polymerization (RAFT) for the azide-alkyne click reaction. For the active targeting of cancer cells folic acid is tethered into the DPPE-p(NIPAM)n by employing thiol-ene click reaction. The structural characterization was carried out by various spectroscopic techniques. The temperature induced self-assembly resulted in micelles (200 nm) capable of controlled release of hydrophobic drug doxorubicin. |
| 저자 |
존슨VJ1, 김일2, 렌지스1
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| 소속 |
1부산대, 2합성고분자 생물접합 하이브리드 사업단 |
| 키워드 |
Lipopolymer; RAFT; Click chemistry; Active targeting; Drug delivery
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| E-Mail |
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