| 학회 |
한국화학공학회 |
| 학술대회 |
2005년 봄 (04/22 ~ 04/23, 여수대학교) |
| 권호 |
11권 1호, p.48 |
| 발표분야 |
고분자 |
| 제목 |
Preparation and Characterization of Low Molecular Water-Soluble Chitosan Nanoparticles Formed Complexes with All-Trans Retinoic Acid |
| 초록 |
The purpose of this study is to develop novel nanoparticles based on polyelectrolyte complexes between water soluble chitosan (WSC) and all-trans retinoic acid (atRA). Chitosan complexes with atRA can be obtained by a simple procedure, i.e. of mixing atRA into chitosan aqueous solution by ultra-sonication. Chitosan nanoparticles encapsulating atRA have spherical shapes with particle size around 100 nm in the transmission electron microscope (TEM) observation. Loading efficiency of atRA into nanoparticles were above 60 % (w/w). From FT-IR spectrum, specific peak of atRA was decreased according to the complex formation between atRA and WSC. Chitosan nanoparticles encapsulating atRA are acceptable for vehicles of atRA. |
| 저자 |
김동곤1, 나재운1, 장미경1, 정영일1, 박준규1, 권중근2
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| 소속 |
1순천대, 2조선이공대 |
| 키워드 |
Low M.W. chitosan; free-amine water-soluble chitosan; ion complex; all-trans retinoic acid
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| E-Mail |
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| 원문파일 |
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