| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Preparation and Characterization of Deoxycholic Acid-Conjugated Low Molecular Weight Water-Soluble Chitosan Nanoparticles for Hydrophobic Antifungal Peptide carrier |
| 초록 |
To develop the carrier of hydrophobic antifungal petide based on Low Molecular Water Soluble Chitosan (LMWSC). LMWSC was chemically modified with Deoxycholic acid (DA) which in one of bile acid as a hydrophobic group. The nanoparticles (LMDA) using DA conjugated LMWSC were characterization using dynamic light scattering(DLS) and transmitance electron microscope (TEM). The loaded peptide as an antimicrobial peptide LMDA nanoparticles (LMDA-A2) were prepared. The release of drug from nanoparticles was slow and showed sustained release characteristics. Based on the results of release study that the higher DA contents in LMDA, the slower the releasing rate, the LMDA-A2 could be used as an exellent antifungal peptide carrier. |
| 저자 |
박준규1, 김태훈1, 남정표1, 김원석1, 최창용1, 박윤경2, 장미경1, 나재운1
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| 소속 |
1순천대, 2조선대 |
| 키워드 |
Helicobacter pylori; Antimicrobial peptide; HP(2-20); LMWSC; Deoxycholic acid.
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| E-Mail |
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