| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Catechol-Functionalized Polyaspartamide Hydrogels Embedded with Silver Nanoparticles for Antimicrobial Properties |
| 초록 |
The increased use of medical devices combined with the emergence of new multi-drug resistant bacteria has focused the research on biomaterials-related infections. Nano-particulate silver has been proven to be highly effective against bacterial infections even at low concentration (0.1-10 ppm). In this study, polyaspartamide-based hydrogels were synthesized by boron-catechol coordination followed by incorporation of AgNPs into the materials. Free catechol moieties were exploited to produce AgNPs. TEM analyses displayed AgNPs with a majority size of less than 20 nm with minimum aggregation, attesting of the role of hydrogels to act as efficient template for the production of dispersed particles. Release kinetics studies were performed in DMEM medium, showing a slow release over a long time-period. Finally, the MIC and MBC were determined to demonstrate a bacteriostatic and bactericidal effect against S. aureus and E. coli. |
| 저자 |
김지흥1, 문종렬1, Milene Tan2, Katharina M. Fromm3
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| 소속 |
1성균관대, 2Univ. of Fribourg, 3Switzerland |
| 키워드 |
silver nanoparticle; catechol; poly(amino acid); hydrogel; antibacterial property
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| E-Mail |
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