| 학회 | 한국공업화학회 |
| 학술대회 | 2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 | 20권 1호 |
| 발표분야 | 생체재료_포스터 |
| 제목 | The enhanced adhesion and proliferation of rabbit BMSCs in RGD-modified MPEG-PCL |
| 초록 | Poly(ethylene glycol)-b-poly(-caprolactone) diblock copolymer (MPEG-PCL) was studied as an injectable biomaterial for in situ-forming scaffold. A major limitation of MPEG-PCL for these applications is the lack of cell-binding sites. In this study, to improve the engraftment of cells, Arg-Gly-Asp (RGD) peptide was conjugated to the end group of MEPG-PCL. Rheological measurements showed a gelation temperature of 37℃ for RGD-conjugated MPEG-PCL. Microscopic studies showed that the clusters of BMSCs were encapsulated into RGD-conjugated MPEG-PCL hydrogel, and BMSCs were attached on the networks of hydrogel by focal adhesion. After 3 days of incubation, BMSCs started to spread and the maximum spreadibility was found at 7 days of incubation. Further, the immobilization of RGD to MPEG-PCL promoted BMSCs viability and differentiation. Acknowledgment : This research was supported by the grant of ministry of Trade, Industry and Energy(MOTIE) (Grant no. 10047811) |
| 저자 | 김현주, 양대혁, 전흥재 |
| 소속 | 가톨릭대 |
| 키워드 | : MPEG-PCL; RGD; MSC; focal adhesion |
