| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Injectable biodegradable MPEG-PCLA diblock copolymer for osteogenic differentiation of human turbinate mesenchymal stem cells |
| 초록 |
Recently, injectable hydrogels have attracted in a wide range of biomedical applications. Here, we examined the utilization as injectable hydrogel of MPEG-b-PCL and MPEG-b-(PCL-ran-PLLA) diblock copolymers for in vivo osteogenic differentiation of human turbinate mesenchymal stem cells (hTMSCs). The aqueous solutions of diblock copolymers existed in an injectable sol-state at room temperature and immediately became a gel-state at body temperature, indicating acting as an injectable in situ-forming hydrogel. The hTMSCs well attached and proliferated on the interconnective pore substrate created by in situ-forming hydrogel. Subcutaneous injection of hTMSCs in the hydrogel demonstrated that hTMSCs in the gel implants showed differentiation toward an osteoblastic phenotype. In conclusion, hTMSCs embedded in an in situ-forming hydrogel may provide numerous benefits as a non-invasive alternative for tissue engineered bone formation. |
| 저자 |
권진선1, 권두연1, 김다연1, 심선우1, Ling Mei Jin1, 박지훈1, 김성원2, 김문석1
|
| 소속 |
1아주대, 2카톨릭대 |
| 키워드 |
Hydrogel; MPEG-PCLA; Osteogenic; hTMSCs
|
| E-Mail |
|
