| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Peripheral nerve regeneration using PCLA nerve guide conduit |
| 초록 |
In the treatment of peripheral nerve defects, the autologous nerve grafts technique has unavoidable disadvantages, such as the limited availability and donor-site morbidity of autografts. Accordingly, many synthetic materials and scaffold fabrication methods have been developed for peripheral nerve regeneration. In this study, we fabricated MPEG-b-(PCL-ran-PLLA) (PCLA) tubular scaffolds by solid freeform fabrication (SFF) and prepared small intestine submucosa (SIS) conduit to compare as the material for nerve regeneration. We confirmed that PCLA conduit has good flexibility, pertinent biodegradability and a less in vivo inflammatory response, indicating tissue biocompatibility. In addition, peripheral nerve regeneration was observed through the staining for nerve cells and Schwann cells. In conclusion, the PCLA conduit can serve as a suitable scaffold for treatment of peripheral nerve defect. |
| 저자 |
권두연1, 심선우1, 권진선1, 박지훈1, 이준희2, 김완두2, 이해방1, 김문석1
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| 소속 |
1아주대, 2한국기계(연) |
| 키워드 |
peripheral nerve; solid freeform fabrication; MPEG-b-(PCL-ran-PLLA); small intestine submucosa; tubular scaffold; conduit
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| E-Mail |
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