| 학회 | 한국재료학회 |
| 학술대회 | 2016년 가을 (11/16 ~ 11/18, 경주 현대호텔) |
| 권호 | 22권 2호 |
| 발표분야 | B. 나노화학/바이오 재료 분과 |
| 제목 | Biodegradable Magnesium Alloy: Shifting the paradigm of conventional bone fixation devices |
| 초록 | Conquering various shortcomings of earlier designs, the concept behind conventional bone fixation device has not been altered for the past century. Fixation devices made out of titanium, stainless steel, or cobalt chrome are being used to fix the fractured bones in place for natural bone remodeling process to mend the broken bones. Recent increase in number of active aging population has escalated the occurrence of bone trauma cases and major flaws of current design, such as inevitable secondary surgery to remove the inert fixation devices after complete bone healing and inflammatory response from metal ions, have surfaced as new challenges. Thus, there has been a significant increase in the research on development of magnesium-based alloys into a new biodegradable implant material. Implants that bio corrode not only repeal the need for second surgery but also avoid the long-term negative effect of permanent implants. Evaluations of regenerated bone on Mg based metals are performed by two viewpoints of fundamental medicine and materials science. Mg based metals were confirmed excellent biocompatibility and regenerated bone on Mg based metals revealed significant improvement of bone formation with the good bone quality. Series of in vivo studies confirmed the great reduction in hydrogen evolution and revealed good tissue compatibility with increased bone deposition around newly developed Mg alloys. Abundance of new bone depositions around the degrading implant sample was observed and minimal new bone formation and bone remodeling were observed as early as 8 weeks after implantation. Newly developed set of KIST magnesium alloys have the mechanical strength, ability to stimulate bone growth and controlled slow degradation rate to be considered as an ideal candidate for biodegradable implant applications. More than 40 patents have been filed and various in vivo and in vitro studies are currently being performed in collaboration with U&I company (http://www.youic.com) to evaluate developed alloy's performance as the degradable bone screw, bone plate, bone graft, dental implant, stent, scaffold, and spinal cage. This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education(2009-0093814) |
| 저자 | 이지욱1, 옥명렬2, 전호정2, 석현광2, 김유찬2, 이강식3 |
| 소속 | 1국민대, 2KIST 생체재료연구단, 3아산병원 |
| 키워드 | <P>Biodegradable metal; Mg alloy; in vivo; bone formation</P> |
