| 학회 |
한국화학공학회 |
| 학술대회 |
2016년 봄 (04/27 ~ 04/29, 부산 BEXCO) |
| 권호 |
22권 1호, p.337 |
| 발표분야 |
분리기술 |
| 제목 |
Serially-ordered magnetization of nanoclusters via control of diverse transition metal dopants for the multi-sorting of cells in microfluidic magnetophoresis devices |
| 초록 |
A novel method (i.e., continuous magnetic cell separation in a microfluidic channel) is demonstrated to be capable of inducing multi-fractionation of mixed cell suspensions into multiple outlet fractions. Here, multi-component cell separation is performed with three different distinguishable magnetic nanoclusters (MnFe2O4, Fe3O4, and CoFe2O4), which are tagged on A431 cells. Due to their magnetization, which can be ideally altered by doping with magnetic atom compositions (Mn, Fe, and Co), the trajectories of cells with each magnetic nanocluster in a flow are shown to be distinct when dragged under the same external magnetic field; the rest of the magnetic characteristics of the nanoclusters are identically fixed. This proof of concept study, which utilizes the magnetic susceptibility-controlled nanoclusters (NCs), suggests that precise and effective multi-fractionation is achievable with high-throughput and systematic accuracy for dynamic cell separation. |
| 저자 |
강병훈1, 한승민1, 신무광1, 장은지1, 김현욱1, 기지선1, 손혜영2, 허용민2, 함승주1
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| 소속 |
1연세대, 2연세의료원 |
| 키워드 |
생물학적 분리 |
| E-Mail |
|
| VOD |
VOD 보기 |
| 원문파일 |
초록 보기 |
