| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Dextran coated magnetic nanoclusters as highly sensitive contrast agents using pyrenyl dextran for magnetic resonance imaging of inflammatory macrophages |
| 초록 |
We fabricated dextran coated magnetic nanocluster (Dex-MNCs) for targeted magnetic resonance imaging of inflammatory macorphages. Dex-MNCs were prepared through encapsulation of hydrophbic magnetic nanocrystals (MNCs) by pyrenyl dextran simultaneously capable of self-seembly as well as surface modification of dextran to strongly interact with macrophages. We confirmed Dex-MNCs exhibited high MR sensitvity by clustered formation of MNCs with biocompatibility and superior uptake ability against macrophages. Consequently, Dex-MNCs were demonstrated to have sufficient capability of targeted macrophage imaging with strengthened MR contrast effect. |
| 저자 |
임은경, 함승주, 허용민
|
| 소속 |
연세대 |
| 키워드 |
magnetic nano crystals; magnetic resonance imaging; dextran; macrophage
|
| E-Mail |
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