| 초록 |
Targeted drug delivery systems have received attention as a specific and effective chemotherapy. Notably, The use of nanoparticles as a drug delivery system has the potential to improve the specificity of anticancer drugs. In this study, we developed hydrogel nanoparticles that respond to temperature and magnetic field using folic acid (FA) as an external ligand. FA specifically binds to GP38 receptor on human cervical cancer cells. We observed higher cellular uptake of nanoparticles in human cervical cancer cells compared to human breast cancer and human fibroblast cells. When the nanoparticles loaded with doxorubicin were treated on human cervical cancer cells, we observed apoptosis of human cervical cancer cells in a time and dose dependent manner. Moreover, drug release was controlled by temperature and magnetic force. In conclusion, our results demonstrated that FA conjugated nanoparticles have potential as a carrier for specific drug delivery tool for anti-cancer therapies. |
