| 학회 |
한국화학공학회 |
| 학술대회 |
2014년 가을 (10/22 ~ 10/24, 대전 DCC) |
| 권호 |
20권 2호, p.2416 |
| 발표분야 |
영어심포지엄(주제미정)(분리기술부문위원회 주제별 심포지엄) |
| 제목 |
Quality-by-Design Approach to Polymorphic Crystallization Development of Pyrazinamide |
| 초록 |
Pyrazinamide is a frontline anti-tuberculosis drug and is on the World Health Organization (WHO) model list of essential medicines. It has four polymorphic forms with stability order of α ＞ δ ＞ γ ＞ β at ambient conditions. The stable α-form is the commercially available form. However, needle-shaped α-form easily forms a mesh-like-structure during filtration leading to inefficient filtration and long drying time. α-form also exhibits poor flowability due to its needle morphology. To avoid these problems, this study attempts to isolate one of the metastable forms which has a better morphology (plate for δ-form or prismatic for γ-form) using Quality-by-Design approach. In this talk, solvent screening results and design space development which ensures consistent production of δ-form will be presented. The robustness of the design space in the presence of various impurities will also be discussed. |
| 저자 |
P. S. Chow1, Martin W. Hermanto1, Alvin C. Y. Yeoh1, Reginald B. H. Tan2
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| 소속 |
1Institute of Chemical and Engineering Sciences, 2Institute of Chemical and Engineering Sciences / National Univ. of Singapore |
| 키워드 |
Pyrazinamide; polymorph; QbD; solvent screening; design space
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| E-Mail |
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| VOD |
VOD 보기 |
| 원문파일 |
초록 보기 |
