| 학회 | 한국화학공학회 |
| 학술대회 | 2021년 가을 (10/27 ~ 10/29, 광주 김대중컨벤션센터) |
| 권호 | 27권 2호, p.1709 |
| 발표분야 | 생물화공 |
| 제목 | Negative pressure cavitation extraction of paclitaxel from Taxus chinensis and its kinetic analysis |
| 초록 | In this study, the recovery efficiency of paclitaxel from Taxus chinensis was remarkably improved through negative pressure cavitation extraction. Most of the paclitaxel could be recovered from the biomass at a negative pressure of -260 mmHg with a one-time extraction in a short operating time (10-20 min). The pseudo-second-order model was suitable for the kinetic analysis, and the diffusion of paclitaxel in the biomass played a dominant role in the overall extraction rate according to the intraparticle diffusion model. As the negative pressure increased (0, -160, -260 mmHg), the extraction rate constant (4.3325-5.9126 mL/mg·min), the effective diffusion coefficient (1.083x10-12-1.377x10-12 m2/s) and the mass transfer coefficient (1.428x10-7-2.371x10-7 m/s) increased. Acknowledgement This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Government of Korea (MSIT) (Grant Number: 2021R1A2C1003186). Keywords: Paclitaxel, Extraction, Negative pressure, Cavitation, Mass transfer kinetics |
| 저자 | 민혜수, 김학균, 김진현 |
| 소속 | 공주대 |
| 키워드 | 생물화학공학 |
| 원문파일 | 초록 보기 |
