| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Pheophorbide A conjugated heparinized magnetic nanoaparticles for simultaneous magnetofluorescence imaging and therapy |
| 초록 |
In this study, photosensitizer conjugated iron oxide nanoparticles (IONPs) were strategically designed and prepared for bimodal cancer imaging and therapy. PheoA conjugated biocompatible heparin were covalently anchored on the surface of IONPs with silane coupling agent which binds on the surface of the nanoparticle. The detailed characterization of the final product reveals the importance of this nanoparticle. We investigated that the covalently incorporated PheoA molecules retained their spectroscopic and functional properties for NIR fluorescence imaging and PDT. And single oxygen detection by laser therapy via UV and photo-lumiscence. In vitro phototoxicity and dark toxicity measure on epithelial cancer (KB) cells. Along with iron oxide nanoparticles offered the functions of magnetically guided drug delivery and MRI. So that prepared single hybrid nanoparticle is a platform for suitable simultaneous photodynamic tumor therapy and dual-mode NIR fluorescence imaging and MRI. |
| 저자 |
Md Nafiujjaman, 강성훈, 이용규
|
| 소속 |
Korea National Univ. of Transportation |
| 키워드 |
Iron oxide; heparin; photodynamic therapy; imaging
|
| E-Mail |
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