| 초록 |
Owing to the outstanding NIR optical properties, graphene quantum dots (GQDs) have promising potential as theranostic agents for fluorescence image-guided drug delivery and noninvasive treatment of deep tumors by photodynamic therapy (PDT). To address these issues, we have developed a biocompatible polydopamine-based theranostic platform for delivery of GQDs and Mn3O4. The synthesis procedure involved the modification of Mn3O4 nanoparticles with biocompatible polydopamine(PDA) via catechol group. In order to make dual imaging guided photodynamic therapy to attach GQDs on surface of polydopamine coated Mn3O4 nanoparticles. The nanoparticles have an average diameter of around 100 nm and 5.81% GQDs contains in a nanoparticles. In an animal tumor model, NPs are efficacious in photodynamic cancer treatment. In addition, MRI studies reveal that the NPs could potentially serve as MRI contrast agents in cancer diagnosis and may be demonstrate as an efficient dual imaging guided PDT. |
