| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 가을 (11/08 ~ 11/10, 부산 벡스코(BEXCO)) |
| 권호 |
21권 2호 |
| 발표분야 |
나노_포스터 |
| 제목 |
Graphene quantum dot-based theranostic agents for enhanced breast cancer treatment |
| 초록 |
A novel graphene quantum dot (GQD)-based nanocarrier labeled with Herceptin (HER) and β-cyclodextrin (β-CD) was developed as a promising theranostic candidate for the treatment of breast cancer. Each component of the nanocarrier plays a critical role in providing multiple functions to achieve enhanced anticancer activities. The nanocarriers also provide diagnostic effects due to the blue-color emission of the GQDs. In response to the acidic environment of cancer cells, the GQD-complex degraded rapidly and the DOX was released in a controlled manner to inhibit proliferation of cancer cells. This multi-functional drug delivery system leads to a synergistically enhanced anticancer strategy which provides treatment and diagnosis. The intracellular trafficking results, along with cell viability and confocal laser scanning microscopy, suggest that the GQD-complex offers a viable strategy for HER2-overexpressed breast cancer-targeting drug delivery applications. |
| 저자 |
고나래1, Md Nafiujjaman2, 이재서1, 이용규2, 권일근1
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| 소속 |
1경희대, 2한국교통대 |
| 키워드 |
Breast cancer; HER2; Graphene quantum dots; Drug delivery system; Active targeting
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| E-Mail |
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