| 초록 |
In this study, reconstructed human skin dermis layers with various mechanical stiffness were fabricated using an ‘Alginate-MA (AL-MA)’ as alginate-based cross-linker. Human skin dermis layers were reconstructed with collagen and various concentration of the AL-MA, which synthesized an alginate modified with methacrylate groups. AL-MA would allow to produce reconstructed dermis layers with elastic modulus (E) between 6.8 ± 0.95 kPa and 33.5 ± 1.45 kPa through Michael addition reaction with collagen fibers and ionic cross-linking. Overall, the results of this study will be highly useful to designing advanced reconstructed human skin equivalents. |
