| 초록 |
Alterations in nuclear morphology are closely associated with essential cell functions and correlate with a wide range of human diseases, including cancer, muscular dystrophy, dilated cardiomyopathy, and progeria. However, the mechanics and forces that shape the nucleus are not well understood. Here we find that 3D confocal reconstruction of major lamin protein lamin A/C forms an apically polarized dome structure in the nucleus of adherent cells. These results show that both A-type lamins and transcriptionally active chromatins are vertically polarized by the tension exercised by the highly contractile actomyosin fibers organized at the apical surface of the nucleus, which regulate the progression of diverse human diseases. |
