| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Controlling Mechanoelectric Microenvironent toInduce Cardiomyogenic Differentiation of Mesenchymal Stem Cells. |
| 초록 | Since mesenchymal stem cells (MSCs) rarelyundergo post-transplantative cardiomyogenic differentiation, ex vivo inductionof cardiomyogenic differentiation of before implantation would potentiatetherapeutic efficacy of stem cell therapies. In cardiac microenvironments,electric pulse and cyclic mechanical strain are sequentially produced. In thisstudy, we suggest a new platform composed of a stretchable piezoelectricsubstrate (SPS) that can provide pulsatile mechanoelectric cues (PMEC) tostimulate cardiomyogenic differentiation of MSCs ex vivo. Along with minimalchemical cue, MSCs underwent expression of cardiac markers by upregulation of autocrinefactor expression, focal adhesion kinase, and extracellular signal-regulatedkinases signaling pathways. |
| 저자 | 윤정기 |
| 소속 | 중앙대 |
| 키워드 | Piezoelectric; cardiomyogenic differentiation; mesenchymal stem cells |
