| 초록 |
Microneedle (MN) has been proposed as a therapeutic device which allow transcutaneous injection of diverse drugs with easily and painlessly. In this study, nano-micelle generating dissolving MN was prepared by a biocompatible amphiphilic tri-block copolymer. When formulate with doxorubicin (DOX) in the MN, the hydrophobic anticancer drug can be dissolved in an aqueous medium by entrapped in nano-micelles generated by dissolution of the MN. The transdermal application of the DOX-incorporated MN can significantly inhibit the growth of melanoma in a mouse skin cancer model. In addition, owing to its small size (＜ 50 nm), the nano-micelle can efficiently migrate to the sentinel lymph nodes, killing the metastatic melanoma cells. Therefore, the use of locally administration of MN can be considered as a promising therapeutic tool for the inhibition of metastatic melanoma. |
