| 초록 |
Synergistic effects of photothermal therapy (PTT) and chemotherapy (CHT) has received considerable attention. The use of gold nanorods (GNRs) can generate localized heat and this heat is used as a source of photothermal energy and drug release. we developed novel system using hyaluronic acid, gold nanorods, and rhodamine B or MTX as model drug. Hyaluronic acid is a biodegradable polymer and is also biocompatible that has a targeting moiety, acting as a antigen of a receptor (CD44) expressed on the surface of cancer cells. Rhodamine B is conjugated to hyaluronic acid by forming ester bond (HA-RhoB). It can have a chemotherapy effect and heat-breakable ester bond. Therefore, rhodamine B can be released by cleaving the ester bond via heat in acidic condition. Furthermore, HA-RhoB is conjugated with gold nanorods by electrostatic force (HA-RhoB-GNRs) that possess synergistic therapeutic efficacy, having a cancer cell targeting moiety. |
