| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 |
25권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Near infrared light-triggered drug release from alginate nanoparticles by bubble generation |
| 초록 |
Herein, we propose alginate-melanin-perfluorohexane (AMP) nanoparticles for near-infrared (NIR) light-triggered drug release by bubble generating through photothermal effect. The AMP nanoparticles had spherical shape with a size of 279.52±0.39 nm and showed no precipitation in physiological fluid. Due to the photothermal properties of melanin, the temperature of the AMP nanoparticles was increased to about 52.9℃ after 808 nm NIR laser irradiation at a power density of 1.5 W/cm2 for 10 min. As perfluorohexane in AMP nanoparticles reached the phase transition temperature by the heat generation of melanin, bubbles were generated effectively. The release rate of methotrexate from the AMP nanoparticles increased rapidly due to the heat generation and bubble generation by laser irradiation. From these results, we expect that AMP nanoparticles can be utilized as promising carriers for controlled drug release by NIR laser irradiation. |
| 저자 |
김현지1, 김민아1, 박지선1, 김진2, 윤순도1, 이창문1
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| 소속 |
1전남대, 2조선대 |
| 키워드 |
Near-infrared laser; Photothermal effect; Melanin; Drug release
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| E-Mail |
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