| 학회 | 한국화학공학회 |
| 학술대회 | 2009년 가을 (10/22 ~ 10/23, 일산 KINTEX) |
| 권호 | 15권 2호, p.1602 |
| 발표분야 | 생물화공 |
| 제목 | The detection of PSA protein biomarker based on resonant Rayleigh light scattering microspectroscopy of individual Au nanoparticles |
| 초록 | A proof-of-concept study was reported on analysis of antigen-antibody recognition based on resonant Rayleigh scattering response of single Au nanoparticles in an imaging chamber. As benefited by a traditional dark-field microscope and a spectrograph, individual Au nanoparticles (30 nm) were observed with high signalto- noise ratio and they were effectively utilized to monitor changes in refractive index induced by specific binding of the adsorbates. Using PSA antigen as a model, a LSPR λmax shift of about 2.85 nm was recorded for a molecular binding corresponding to 0.1 pgml-1of the protein biomarker. This result successfully demonstrates a nonlabeling detection system for proteins. |
| 저자 | 황우성, 심상준 |
| 소속 | 성균관대 |
| 키워드 | LSPR; Resonant Rayleigh light scattering |
| 원문파일 | 초록 보기 |
