| 초록 |
In this study, we investigated the kinetics and thermodynamics of microwave-assisted drying of paclitaxel for the removal of residual solvent, methylene chloride. The efficiency of microwave-assisted drying increased with increasing drying temperature. When the experimental data were applied to various kinetic models, the Newton model, Henderson and Pabis model, Page model, Modified Page model, and the Geometric model were acceptable. Among the kinetic models, the Page model was the most appropriate. The activation energy Ea of microwave-assisted drying was found to be 46.21 kJ/mol. The Gibbs free energy change was determined to be negative, while enthalpy change and entropy change were positive. These results indicate that this extraction process was spontaneous, endothermic, and irreversible in nature. Acknowledgment This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education, Science and Technology (Grant Number: 2015016271). |
