| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생체재료 |
| 제목 |
Antibody-mediated oral GLP-1 gene delivery to treat type 2 diabetes |
| 초록 |
Diabetes mellitus is a global epidemic associated with uncontrolled elevation of blood glucose levels. GLP-1 prevents type 2 diabetic patients from experiencing hyperglycemic episodes without concern of unexpected hypoglycemic situation from conventional insulin treatment. However, the short half-life and rapid clearance of GLP-1 often limit its therapeutic use. Here we developed an oral GLP-1 gene delivery system to extend the antidiabetic effect of GLP-1. A nanocomplex for oral GLP-1 gene delivery has consisted of GLP-1 gene and vehicle with protamine and hIgG-Fc, an Fc segment from an FcRn receptor-specific antibody. The nanocomplex showed superior stability against pH fluctuation and enzymatic digestion in the gastrointestinal tract, and high cellular uptake to the intestinal cells. The functional expression of GLP-1 also led to the extended antidiabetic effect of GLP-1 in type 2 diabetic mice, suggesting a promise for the treatment of type 2 diabetes mellitus. |
| 저자 |
Mohammad Nazmul Hasan, 김다혜, 이지훈, 황주나, 조성필, 이용규
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| 소속 |
한국교통대 |
| 키워드 |
GLP-1; hIgG-Fc; FcRn; type 2 diabetes mellitus
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| E-Mail |
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