| 학회 | 한국공업화학회 |
| 학술대회 | 2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 | 25권 1호 |
| 발표분야 | [정밀화학] 정밀화학 기술 - COVID-19 시대 |
| 제목 | Development of β-lactam-based chemical probes for detection of antibiotic resistant bacteria |
| 초록 | Current detection methods of β-lactamase producing bacteria can be categorized into phenotypic and genotypic methods. The genotypic methods based on molecular diagnostics are accurate but they can detect only the genes of which sequence is known. Alternatively, many phenotypic methods have been reported, whereas they are still time-consuming and lack of sensitivity and specificity. Most recently, activity-based detection methods have been developed to overcome these disadvantages. In particular, fluorescence-based assays are attractive owing to relatively low cost, high sensitivity and operational simplicity. Herein, we report synthesis and evaluation of novel fluorogenic β-lactamase substrates for the specific detection of the β-lactamase-producing antibiotic resistant bacteria. The result from clinical assessment of our probes indicated that they would provide practical screening tools for rapid and accurate detection of the antibiotic resistant bacteria. |
| 저자 | 민선준 |
| 소속 | 한양대 |
| 키워드 | beta-lactam; chemical probes; antibiotic resistance |
