| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 |
20권 1호 |
| 발표분야 |
(생물공학)시스템/합성생물학과 생체분자공학 최신기술 |
| 제목 |
Artificial hypoxic microenvironments for vascular tissue regeneration |
| 초록 |
Oxygen is vital for the existence of all multicellular organisms, acting as a signaling molecule regulating cellular activities. In particular, hypoxia is recognized as a key regulator that promotes vascular development in various biological processes. Here we report a hypoxia-inducible (HI) hydrogels that can form hydrogel networks via oxygen consumption in a laccase-mediated reaction. Oxygen levels and gradients within the hydrogels can be accurately controlled and precisely predicted. We demonstrate that HI hydrogels guide vascular morphogenesis in vitro via hypoxia-inducible factors activation and promote rapid neovascularization from the host tissue during subcutaneous wound healing. The HI hydrogel is a new class of biomaterials that may prove useful in many applications, ranging from fundamental studies of developmental, regenerative and disease processes through the engineering of healthy and diseased tissue models towards the treatment of hypoxia- regulated disorders.
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| 저자 |
박경민 |
| 소속 |
인천대 |
| 키워드 |
Polymeric hydrogels; hypoxia
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| E-Mail |
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