| 초록 |
Local anesthetic agents are commonly adapted to relief pain after surgery, trauma, or medical procedures by blocking of propagation of the nerve impulse. Although the local anesthetics are introduced for human in the 1800’s, their safety and prolonged activity issues are still remained as significant challenge for clinical practices. To compensate the limitations, the encapsulation of local anesthetics in liposomes and biodegradable polymers are recently introduced. However, the difficult manufacturing procedures, toxicity of metabolite compounds and sometimes unexpected burst release are also reported. In this study, we developed an ion-complexed lidocaine which can allow the sustained release of the local anesthetic for sufficient period (~ 24 hrs) without any additional biomaterials. The drug release behavior, cytotoxicity, and analgesic effect in the body of the ion-complexed lidocaine were investigated. |
