| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 봄 (04/29 ~ 05/01, BEXCO (부산)) |
| 권호 |
19권 1호 |
| 발표분야 |
생물공학_포스터 |
| 제목 |
Sustained release of anti-tumor drug molecules from engineered self-expanding hydrogels |
| 초록 |
We synthesized copolymer of hydrogel composed of methyl-methacrylate and N-vinyl-2-pyrrolidone and in vitro release of anti-cancer drug doxorubicin from the self-expanded hydrogel in a physiological condition. The degree of expansion of self-expander copolymer was measured in various solutions. We induced absorption of drug through self-expansion caused by osmotic pressure into hydrogel composed of methyl methacrylate and N-vinyl-2-pyrrolidone. Anti-tumor effects of released drug molecules were evaluated with MDA-MB-231 breast carcinoma cell. Drug contained self-expander hydrogel may have a potential in biomedical applications, for example, implantation at the tissue area that requires physical support as well as anti-inflammatory drug release. |
| 저자 |
최종훈1, 김지은1, 김동명2, 강호창2, 서영민1, 황장선1, 정윤1, 이관홍1
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| 소속 |
1한양대, 2프로바이오미메틱스(연) |
| 키워드 |
self-expander; hydorgel; drug delivery
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| E-Mail |
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