| 초록 |
Chemo-photodynamic therapy has received great interests as the promising treatment modality. Herein, we developed a novel theranostic nanoscale drug delivery system (nDDS), which combines chemotherapy and photodynamic therapy (PDT) into modified single platform to achieve synergistic effects of these therapies on the treatment of drug resistant cancer cell. We synthesized chemo-photodynamic agents, amphiphilic benzyl poly (ethylene glycol)-diiodo substituted BODIPY conjugated with cisplatin (bPEG-DIBOC). The cellular cisplatin uptake derived from the bPEG-DIBOC nanoparticles was much higher than that derived from cisplatin in cisplatin-resistant A549/DDP lung cancer cells. The bPEG-DIBOC showed distinguished anticancer effects against A549/DDP cells with much lower concentration (0.63μM) than free cisplatin (10μM). Consequently, this study proposes the outstanding potential of nDDS-based chemo-photodynamic therapeutic agent to circumvent drug resistance. |
