| 초록 |
Hollow MnO nanocubes have been fabricated and modified by either ligand exchange or ligand encapsulation, to render them water-soluble. A phthalate buffer solution (pH 4.0) has been used to induce the formation of hollow nanosphere structures. An increase in the nanoparticle surface percentage of these as-synthesized nanocubes allows for enhanced water accessibility, leading to higher R1 relaxivity. Ligand exchange, as well as the presence of a hollow structure, tremendously increases the surface area-to-volume ratio, resulting in increased accessibility of water protons to the exposed metal ions. Magnetic resonance imaging (MRI) experiments reveal that hollow ligand-exchanged MnO nanocubes can exhibit significantly enhanced longitudinal relaxation times by allowing direct contact with water protons. Furthermore, in vivo MRI investigations reveal that the particles can be used effectively as T1 magnetic resonance contrast agents. |
