| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Preparation and Evaluation of Chitosan/PLGA bilayered Nanofiber for Anti-adhesion Barrier |
| 초록 |
Post-operative peritoneal adhesions are common and give serious complications for surgeons. They can cause pelvic pain, infertility, and potentially lethal bowel obstruction. In this study, we fabricated and evaluated the effect of bilayer sheet containing non-steroidal anti-inflammatory drug on the prevention of post-surgical tissue adhesion. For this, bilayered nanofibrous sheets composed of chitosan and poly(lactide-co-glycolide)(PLGA) with polyvinylpyrrolidone(PVP) were fabricated by electrospinning method. The bilayered Chitosan/PLGA nanofibrous sheet was characterized by several spectroscopic methods. Mechanical properties and in vitro results showed that bilayered Chitosan/PLGA nanofibrous sheet was suitable for anti-adhesion barrier. From in vivo animal test, it was observed that bilayered nanofibrous sheets were significantly effective in preventing post-operative adhesion and wound healing. |
| 저자 |
이재백1, 김선종1, 김원일2, 권오경3, 권오형1
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| 소속 |
1금오공과대, 2원바이오젠, 3칠곡경북대 |
| 키워드 |
Electrospinning; Anti-adhesion; Chitosan; PLGA; Bilayer sheet
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| E-Mail |
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