| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Evaluation of bioabsorbable nanofibrous hemostatic mat containing blood coagulation agents |
| 초록 |
Hemostatic agents have been used in surgical operation for many years to control bleeding. In this study, we fabricated poly(vinyl pyrrolidone)(PVP) nanofibrous mats containing blood coagulation agents such as calcium chloride and thrombin to use as a novel non-woven hemostatic agent. PVP is inexpensive and safe material approved by FDA for human use. PVP nanofibrous sheets were fabricated by electrospinning of PVP aqueous ethanol solution containing thrombin and calcium chloride. PVP nanofibers showed a relatively low cytotoxicity and the cellular survival rate was more than 90%. In vitro whole blood coagulation experiment showed expeditious blood coagulation within 3 minutes after contact with fabricated nanofibrous sheet, In vivo studies using haemorrhaging liver rat model showed great promise of PVP nanofibers to aid in rapid hemostasis. These results suggest that electrospun PVP nanofibrous mats will be a promising hemostatic agent to reduce massive blood loss. |
| 저자 |
권오형1, 김은진2, 김선종2, 심은정1, 한서희1
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| 소속 |
1금오공과대, 2M.I Tech |
| 키워드 |
PVP; hemostatic agents; blood coagulation agents; bioabsorbable
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| E-Mail |
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