| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터) |
| 권호 |
42권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II (영어발표) |
| 제목 |
Multifunctional nanofibrous meshes for delivering therpeutics gene and proteins |
| 초록 |
Multifunctional nanofibrous meshes were fabricated by electrospinning techniques for local delivery of therapeutics gene on the wound sites. We also prepared a double-layered electrospun nanofibrous sheets composed of Eudragit and chitosan to accelerate the healing rate of oral mucous ulcer. In vivo study employing oral ulcers in dogs, the ulcers dressed with chitosan-layered sheets showed enhanced wound recovery and the chitosan layers on the sheet greatly assisted prolonged recovery. An in vivo fluorescence resonance energy transfer (FRET) study also revealed that the clusters were effectively dissociated in MMP-rich environments of dorsal wounds in diabetic animals. In addition, diabetic ulcers treated with the clusters showed a faster wound closure rate and the recovered tissue expressed a larger amount of cytokeratin along with a lower expression level of MMP-2 compared to the other groups. |
| 저자 |
유혁상, 김혜성, 손영주, 이솔, 강면구, 최지숙, wei mao
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| 소속 |
강원대 |
| 키워드 |
nanofiber; surface; decoration
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| E-Mail |
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